Sickle cell anemia is more prevalent in African and African Americans because having one allele was crucial for survival in Africa especially south of the Sahara desert. This is one main reason why sickle cell anemia does not present itself in other races is because this mutation occurred to protect the population of South Africa. This mutation spread throughout this region over generations. Giving the individuals that possessed one copy of the gene a resistance to malaria. Thus giving the population contain one gene a better chance at survival and becoming common in that region. So even though this seems race related it is not, it is geographically related. Now that is explained to look at the disease sickle cell anemia itself, it is when both parents pass on a sickle cell gene to a child. To do this the obvious thing is that the parents have to contain the gene and to contain the gene they would have to be or have ancestors from South Africa. Most people in and from that region are black and that is why the disease is associated with black individuals. Then if both parents do pass on a sickle cell gene instead of it being a good thing for fighting malaria it is a bad thing for everyday life. It then takes an evolutionary adaptation that is beneficial and turns it into a disease when two genes are present. What this does is whenever someone that has sickle cell anemia exerts themselves too much they run the risk of having a sickle cell emergency. This is when all the red blood cells twist and this causes great pain to the individual along with making it hard to breath. This is because the red blood cells are the ones that carry the oxygen throughout the body. Also when the blood cells sickle they clog up veins and arteries in the body, this is what causes a lot of the pain during these episodes. So even though this disease seems racially related on the surface it is related geographically because of the problem with malaria that made this mutation important.
“Modern Theories of Evolution: Natural Selection.” Modern Theories of Evolution: Natural Selection. Accessed July 13, 2016. http://anthro.palomar.edu/synthetic/synth_4.htm.